Incubation of ovine scrapie with environmental matrix results in biological and biochemical changes of PrP(Sc) over time

Ovine scrapie can be transmitted via environmental reservoirs. A pool of ovine scrapie isolates were incubated on soil for one day or thirteen months and eluted prion was used to challenge tg338 mice transgenic for ovine PrP. After one-day incubation on soil, two PrP(Sc) phenotypes were present: G(3...

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Detalhes bibliográficos
Publicado no:Vet Res
Main Authors: Maddison, Ben C, Spiropoulos, John, Vickery, Christopher M, Lockey, Richard, Owen, Jonathan P, Bishop, Keith, Baker, Claire A, Gough, Kevin C
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4415298/
https://ncbi.nlm.nih.gov/pubmed/25928902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13567-015-0179-y
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