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PrP(c) Does Not Mediate Internalization of PrP(Sc) but Is Required at an Early Stage for De Novo Prion Infection of Rov Cells

We have studied the interactions of exogenous prions with an epithelial cell line inducibly expressing PrP(c) protein and permissive to infection by a sheep scrapie agent. We demonstrate that abnormal PrP (PrP(Sc)) and prion infectivity are efficiently internalized in Rov cells, whether or not PrP(c...

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Autors principals: Paquet, Sophie, Daude, Nathalie, Courageot, Marie-Pierre, Chapuis, Jérôme, Laude, Hubert, Vilette, Didier
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045457/
https://ncbi.nlm.nih.gov/pubmed/17626095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01137-07
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