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PrP(c) Does Not Mediate Internalization of PrP(Sc) but Is Required at an Early Stage for De Novo Prion Infection of Rov Cells
We have studied the interactions of exogenous prions with an epithelial cell line inducibly expressing PrP(c) protein and permissive to infection by a sheep scrapie agent. We demonstrate that abnormal PrP (PrP(Sc)) and prion infectivity are efficiently internalized in Rov cells, whether or not PrP(c...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology
2007
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2045457/ https://ncbi.nlm.nih.gov/pubmed/17626095 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01137-07 |
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