Processing of Open Reading Frame 1a Replicase Proteins nsp7 to nsp10 in Murine Hepatitis Virus Strain A59 Replication

Coronaviruses express open reading frame 1a (ORF1a) and ORF1b polyproteins from which 16 nonstructural proteins (nsp) are derived. The highly conserved region at the carboxy terminus of ORF1a is processed by the nsp5 proteinase (M(pro)) into mature products, including nsp7, nsp8, nsp9, and nsp10, pr...

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Bibliographic Details
Main Authors: Deming, Damon J., Graham, Rachel L., Denison, Mark R., Baric, Ralph S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2007
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045455/
https://ncbi.nlm.nih.gov/pubmed/17634238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00017-07
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