Murine Hepatitis Virus Replicase Protein nsp10 Is a Critical Regulator of Viral RNA Synthesis

Coronavirus replication requires proteolytic processing of the large polyprotein encoded by ORF1a/ab into putative functional intermediates and eventually ∼15 mature proteins. The C-terminal ORF1a protein nsp10 colocalizes with viral replication complexes, but its role in transcription/replication i...

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Bibliografiske detaljer
Main Authors: Donaldson, Eric F., Sims, Amy C., Graham, Rachel L., Denison, Mark R., Baric, Ralph S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2007
Fag:
Genome Replication and Regulation of Viral Gene Expression
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1900072/
https://ncbi.nlm.nih.gov/pubmed/17392363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02805-06
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