Severe Acute Respiratory Syndrome Coronavirus Group-Specific Open Reading Frames Encode Nonessential Functions for Replication in Cell Cultures and Mice

SARS coronavirus (SARS-CoV) encodes several unique group-specific open reading frames (ORFs) relative to other known coronaviruses. To determine the significance of the SARS-CoV group-specific ORFs in virus replication in vitro and in mice, we systematically deleted five of the eight group-specific...

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Detalhes bibliográficos
Main Authors: Yount, Boyd, Roberts, Rhonda S., Sims, Amy C., Deming, Damon, Frieman, Matthew B., Sparks, Jennifer, Denison, Mark R., Davis, Nancy, Baric, Ralph S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1287583/
https://ncbi.nlm.nih.gov/pubmed/16282490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.23.14909-14922.2005
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