p21 is decreased in polycystic kidney disease and leads to increased epithelial cell cycle progression: roscovitine augments p21 levels

BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disease with few treatment options other than renal replacement therapy. p21, a cyclin kinase inhibitor which has pleiotropic effects on the cell cycle, in many cases acts to suppress cell cycle progression and to p...

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Autors principals: Park, Jin-Young, Schutzer, William E, Lindsley, Jessie N, Bagby, Susan P, Oyama, Terry T, Anderson, Sharon, Weiss, Robert H
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2007
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045080/
https://ncbi.nlm.nih.gov/pubmed/17714589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2369-8-12
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