Attenuated Free Cholesterol Loading-induced Apoptosis but Preserved Phospholipid Composition of Peritoneal Macrophages from Mice That Do Not Express Group VIA Phospholipase A(2)

Previous studies suggest that group VIA phospholipase A(2) (iPLA(2)β) participates in endoplasmic reticulum (ER) stress-induced apoptosis, and mouse macrophages undergo ER stress and apoptosis upon free cholesterol loading (FCL). We recently generated iPLA(2)β-null mice, and here we demonstrate that...

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Main Authors: Bao, Shunzhong, Li, Yankun, Lei, Xiaoyong, Wohltmann, Mary, Jin, Wu, Bohrer, Alan, Semenkovich, Clay F., Ramanadham, Sasanka, Tabas, Ira, Turk, John
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2044506/
https://ncbi.nlm.nih.gov/pubmed/17627946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M701316200
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