Development of Resistance in Wild-Type and Hypermutable Pseudomonas aeruginosa Strains Exposed to Clinical Pharmacokinetic Profiles of Meropenem and Ceftazidime Simulated In Vitro

In this study we investigated the interplay of antibiotic pharmacokinetic profiles and the development of mutation-mediated resistance in wild-type and hypermutable Pseudomonas aeruginosa strains. We used in vitro models simulating profiles of the commonly used therapeutic drugs meropenem and ceftaz...

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Bibliografiska uppgifter
Huvudupphovsmän: Henrichfreise, Beate, Wiegand, Irith, Luhmer-Becker, Ingeborg, Wiedemann, Bernd
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2007
Ämnen:
Experimental Therapeutics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043282/
https://ncbi.nlm.nih.gov/pubmed/17682103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00160-07
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