Efficacy of High-Dose Meropenem (Six Grams per Day) in Treatment of Experimental Murine Pneumonia Induced by Meropenem-Resistant Pseudomonas aeruginosa

High-dose meropenem (MEPM; 6 g/day) has been approved as a treatment for purulent meningitis; however, little is known regarding its in vivo efficacy in refractory lower respiratory tract infections. The purpose of this study was to evaluate the efficacy of MEPM at 6 g/day in a murine model of sever...

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Опубликовано в: :Antimicrob Agents Chemother
Главные авторы: Oshima, Kazuhiro, Nakamura, Shigeki, Iwanaga, Naoki, Takemoto, Koji, Miyazaki, Taiga, Yanagihara, Kastunori, Miyazaki, Yoshitsugu, Mukae, Hiroshi, Kohno, Shigeru, Izumikawa, Koichi
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2016
Предметы:
Experimental Therapeutics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5192154/
https://ncbi.nlm.nih.gov/pubmed/27799201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02056-16
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