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Discovery of Novel DNA Gyrase Inhibitors by High-Throughput Virtual Screening
The bacterial type II topoisomerases DNA gyrase and topoisomerase IV are validated targets for clinically useful quinolone antimicrobial drugs. A significant limitation to widely utilized quinolone inhibitors is the emergence of drug-resistant bacteria due to an altered DNA gyrase. To address this p...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2043263/ https://ncbi.nlm.nih.gov/pubmed/17682095 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00392-07 |
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