Discovery of Selective Inhibitors Against EBNA1 via High Throughput In Silico Virtual Screening

BACKGROUND: Epstein-Barr Virus (EBV) latent infection is associated with several human malignancies and is a causal agent of lymphoproliferative diseases during immunosuppression. While inhibitors of herpesvirus DNA polymerases, like gancyclovir, reduce EBV lytic cycle infection, these treatments ha...

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Main Authors: Li, Ning, Thompson, Scott, Schultz, David C., Zhu, Weiliang, Jiang, Hualiang, Luo, Cheng, Lieberman, Paul M.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2010
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853575/
https://ncbi.nlm.nih.gov/pubmed/20405039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010126
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