Population Pharmacokinetics and Pharmacodynamics of Continuous versus Short-Term Infusion of Imipenem-Cilastatin in Critically Ill Patients in a Randomized, Controlled Trial

Beta-lactams are regularly administered in intermittent short-term infusions. The percentage of the dosing interval during which free drug concentrations exceed the MIC (fT(>MIC)) is the measure of drug exposure that best correlates with clinical outcome for beta-lactams. Therefore, administratio...

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Detalhes bibliográficos
Main Authors: Sakka, Samir G., Glauner, Anna K., Bulitta, Jürgen B., Kinzig-Schippers, Martina, Pfister, Wolfgang, Drusano, George L., Sörgel, Fritz
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Clinical Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043189/
https://ncbi.nlm.nih.gov/pubmed/17620371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01318-06
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