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Cyclodextrins sequester neuroactive steroids and differentiate mechanisms that rate limit steroid actions
BACKGROUND AND PURPOSE: Neuroactive steroids are potent modulators of GABA(A) receptors and are thus of interest for their sedative, anxiolytic, anticonvulsant and anaesthetic properties. Cyclodextrins may be useful tools to manipulate neuroactive effects of steroids on GABA(A) receptors because cyc...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2042897/ https://ncbi.nlm.nih.gov/pubmed/17160009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706973 |
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