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Characterization of the human cytochrome P450 enzymes involved in the metabolism of dihydrocodeine
Aims Using human liver microsomes from donors of the CYP2D6 poor and extensive metabolizer genotypes, the role of individual cytochromes P-450 in the oxidative metabolism of dihydrocodeine was investigated. Methods The kinetics of formation of N- and O-demethylated metabolites, nordihydrocodeine and...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
1997
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2042888/ https://ncbi.nlm.nih.gov/pubmed/9431830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1997.t01-1-00626.x |
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