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Analysis of the dihydropyrimidine dehydrogenase polymorphism in a British population

Subjects with low or absent dihydropyrimidine dehydrogenase activity (DPD) are at risk of excessive toxicity or death when undergoing fluoropyrimidine chemotherapy. The DPD polymorphism has not been well characterized in the general population and the frequency of the enzyme deficiency is not known....

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Autori principali: McMURROUGH, J., McLEOD, H. L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1996
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2042607/
https://ncbi.nlm.nih.gov/pubmed/8735686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1996.34212.x
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