A Cardiovascular Drug Rescues Mice from Lethal Sepsis by Selectively Attenuating a Late-Acting Proinflammatory Mediator, High Mobility Group Box 1

The pathogenesis of sepsis is mediated in part by bacterial endotoxin, which stimulates macrophages/monocytes to sequentially release early (e.g., TNF, IL-1, and IFN-γ) and late (e.g., high mobility group box 1 (HMGB1) protein) proinflammatory cytokines. The recent discovery of HMGB1 as a late media...

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Hlavní autoři: Li, Wei, Li, Jianhua, Ashok, Mala, Wu, Rongqian, Chen, Dazhi, Yang, Lihong, Yang, Huan, Tracey, Kevin J., Wang, Ping, Sama, Andrew E., Wang, Haichao
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2041900/
https://ncbi.nlm.nih.gov/pubmed/17339485
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