Alzheimer’s-specific effects of soluble β-amyloid on protein kinase C-α and -γ degradation in human fibroblasts

Alzheimer’s disease (AD) is a multifactorial disease in which β-amyloid peptide (βAP) plays a critical role. We report here that the soluble fraction 1–40 of βAP differentially degrades protein kinase C-α and -γ (PKCα and PKCγ) isoenzymes in normal (age-matched controls, AC) and AD fibroblasts most...

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Autores principales: Favit, Antonella, Grimaldi, Maurizio, Nelson, Thomas J., Alkon, Daniel L.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 1998
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC20417/
https://ncbi.nlm.nih.gov/pubmed/9576922
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