Alzheimer’s-specific effects of soluble β-amyloid on protein kinase C-α and -γ degradation in human fibroblasts

Alzheimer’s disease (AD) is a multifactorial disease in which β-amyloid peptide (βAP) plays a critical role. We report here that the soluble fraction 1–40 of βAP differentially degrades protein kinase C-α and -γ (PKCα and PKCγ) isoenzymes in normal (age-matched controls, AC) and AD fibroblasts most...

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Xehetasun bibliografikoak

Argitaratua izan da:	Proc Natl Acad Sci U S A
Egile Nagusiak:	Favit, Antonella, Grimaldi, Maurizio, Nelson, Thomas J., Alkon, Daniel L.
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	National Academy of Sciences 1998
Gaiak:	Biological Sciences
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20417/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9576922/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.10.5562
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