Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults

Individual variation in fetal hemoglobin (HbF, α(2)γ(2)) response underlies the remarkable diversity in phenotypic severity of sickle cell disease and β thalassemia. HbF levels and HbF-associated quantitative traits (e.g., F cell levels) are highly heritable. We have previously mapped a major quanti...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Thein, Swee Lay, Menzel, Stephan, Peng, Xu, Best, Steve, Jiang, Jie, Close, James, Silver, Nicholas, Gerovasilli, Ageliki, Ping, Chen, Yamaguchi, Masao, Wahlberg, Karin, Ulug, Pinar, Spector, Tim D., Garner, Chad, Matsuda, Fumihiko, Farrall, Martin, Lathrop, Mark
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2007
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040901/
https://ncbi.nlm.nih.gov/pubmed/17592125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611393104
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