Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults

Individual variation in fetal hemoglobin (HbF, α(2)γ(2)) response underlies the remarkable diversity in phenotypic severity of sickle cell disease and β thalassemia. HbF levels and HbF-associated quantitative traits (e.g., F cell levels) are highly heritable. We have previously mapped a major quanti...

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Hauptverfasser: Thein, Swee Lay, Menzel, Stephan, Peng, Xu, Best, Steve, Jiang, Jie, Close, James, Silver, Nicholas, Gerovasilli, Ageliki, Ping, Chen, Yamaguchi, Masao, Wahlberg, Karin, Ulug, Pinar, Spector, Tim D., Garner, Chad, Matsuda, Fumihiko, Farrall, Martin, Lathrop, Mark
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2007
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040901/
https://ncbi.nlm.nih.gov/pubmed/17592125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611393104
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