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Sphingosine 1-Phosphate pK(a) and Binding Constants: Intramolecular and Intermolecular Influences
The dissociation constant for an ionizable ligand binding to a receptor is dependent on its charge and therefore on its environmentally-influenced pK(a) value. The pK(a) values of sphingosine 1-phosphate (S1P) were studied computationally in the context of the wild type S1P(1) receptor and the follo...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2040500/ https://ncbi.nlm.nih.gov/pubmed/17467317 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmgm.2007.03.004 |
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