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EGF receptor ubiquitination is not necessary for its internalization
Ubiquitination of the EGF receptor (EGFR) has been implicated in EGF-induced receptor internalization, lysosomal degradation, and down-regulation. Mutation of EGFR ubiquitination sites identified by mass spectrometry yielded receptor mutants that are weakly ubiquitinated and not down-regulated by EG...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2007
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2040475/ https://ncbi.nlm.nih.gov/pubmed/17940017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707416104 |
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