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The role of EGF receptor ubiquitination in regulating its intracellular traffic
Progression of activated EGF receptor (EGFR) through the endocytic pathway regulates EGFR signaling. Here we show that a non-ubiquitinated EGFR mutant, unable to bind the endosomal sorting complex required for transport (ESCRT) component, Hrs, is not efficiently targeted onto intraluminal vesicles (...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3261333/ https://ncbi.nlm.nih.gov/pubmed/22017370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0854.2011.01305.x |
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