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Architecture of the yeast Rrp44–exosome complex suggests routes of RNA recruitment for 3′ end processing

The eukaryotic core exosome (CE) is a conserved nine-subunit protein complex important for 3′ end trimming and degradation of RNA. In yeast, the Rrp44 protein constitutively associates with the CE and provides the sole source of processive 3′-to-5′ exoribonuclease activity. Here we present EM recons...

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Detalhes bibliográficos
Main Authors: Wang, Hong-Wei, Wang, Jianjun, Ding, Fang, Callahan, Kevin, Bratkowski, Matthew A., Butler, J. Scott, Nogales, Eva, Ke, Ailong
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040474/
https://ncbi.nlm.nih.gov/pubmed/17942686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705526104
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