The N-terminal PIN domain of the exosome subunit Rrp44 harbors endonuclease activity and tethers Rrp44 to the yeast core exosome

Nuclear and cytoplasmic forms of the yeast exosome share 10 components, of which only Rrp44/Dis3 is believed to possess 3′ exonuclease activity. We report that expression only of Rrp44 lacking 3′-exonuclease activity (Rrp44-exo) supports growth in S288c-related strains (BY4741). In BY4741, rrp44-exo...

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Bibliographic Details
Main Authors: Schneider, Claudia, Leung, Eileen, Brown, Jeremy, Tollervey, David
Format: Artigo
Language:Inglês
Published: Oxford University Press 2009
Subjects:
Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651783/
https://ncbi.nlm.nih.gov/pubmed/19129231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn1020
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