Altered phase diagram due to a single point mutation in human γD-crystallin

The P23T mutant of human γD-crystallin (HGD) is associated with cataract. We have previously investigated the solution properties of this mutant, as well as those of the closely related P23V and P23S mutants, and shown that although mutations at site 23 of HGD do not produce a significant structural...

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Detaylı Bibliyografya
Asıl Yazarlar: McManus, Jennifer J., Lomakin, Aleksey, Ogun, Olutayo, Pande, Ajay, Basan, Markus, Pande, Jayanti, Benedek, George B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2007
Konular:
Physical Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040415/
https://ncbi.nlm.nih.gov/pubmed/17923670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707412104
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