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Altered phase diagram due to a single point mutation in human γD-crystallin
The P23T mutant of human γD-crystallin (HGD) is associated with cataract. We have previously investigated the solution properties of this mutant, as well as those of the closely related P23V and P23S mutants, and shown that although mutations at site 23 of HGD do not produce a significant structural...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2040415/ https://ncbi.nlm.nih.gov/pubmed/17923670 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707412104 |
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