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Chemical modification resolves the asymmetry of siRNA strand degradation in human blood serum
Small interfering (si)RNAs have recently been used to therapeutically silence genes in vivo after intravenous systemic delivery. Further progress in the development of siRNA therapeutics will in part rely on tailoring site-specific chemical modifications of siRNAs to optimize their pharmacokinetic p...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2040087/ https://ncbi.nlm.nih.gov/pubmed/17804643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.602307 |
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