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Molecular Determinants of Antibiotic Recognition and Resistance by Aminoglycoside Phosphotransferase (3′)-IIIa: A Calorimetric and Mutational Analysis
The growing threat from the emergence of multidrug resistant pathogens highlight a critical need to expand our currently available arsenal of broad-spectrum antibiotics. In this connection, new antibiotics must be developed that exhibit the abilities to circumvent known resistance pathways. An impor...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2040079/ https://ncbi.nlm.nih.gov/pubmed/17418235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.02.103 |
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