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Molecular Determinants of Antibiotic Recognition and Resistance by Aminoglycoside Phosphotransferase (3′)-IIIa: A Calorimetric and Mutational Analysis

The growing threat from the emergence of multidrug resistant pathogens highlight a critical need to expand our currently available arsenal of broad-spectrum antibiotics. In this connection, new antibiotics must be developed that exhibit the abilities to circumvent known resistance pathways. An impor...

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Detalhes bibliográficos
Main Authors: Kaul, Malvika, Barbieri, Christopher M., Srinivasan, Annankoil R., Pilch, Daniel S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040079/
https://ncbi.nlm.nih.gov/pubmed/17418235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.02.103
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