Complete Thermodynamic Characterization of the Multiple Protonation Equilibria of the Aminoglycoside Antibiotic Paromomycin: A Calorimetric and Natural Abundance (15)N NMR Study

The binding of aminoglycoside antibiotics to a broad range of macromolecular targets is coupled to protonation of one or more of the amino groups that typify this class of drugs. Determining how and to what extent this linkage influences the energetics of the aminoglycoside-macromolecule binding rea...

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Bibliographic Details
Main Authors: Barbieri, Christopher M., Pilch, Daniel S.
Format: Artigo
Language:Inglês
Published: Biophysical Society 2006
Subjects:
Nucleic Acids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1367285/
https://ncbi.nlm.nih.gov/pubmed/16326918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.075028
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