Transient kinetics of aminoglycoside phosphotransferase(3′)-IIIa reveals a potential drug target in the antibiotic resistance mechanism

Aminoglycoside phosphotransferases are bacterial enzymes responsible for the inactivation of aminoglycoside antibiotics by O-phosphorylation. It is important to understand the mechanism of enzymes in order to find efficient drugs. Using rapid-mixing methods, we studied the transient kinetics of amin...

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Detalhes bibliográficos
Main Authors: Lallemand, Perrine, Leban, Nadia, Kunzelmann, Simone, Chaloin, Laurent, Serpersu, Engin H., Webb, Martin R., Barman, Tom, Lionne, Corinne
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science B.V 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510435/
https://ncbi.nlm.nih.gov/pubmed/23108046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2012.10.027
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