Recombinant human parainfluenza virus type 2 vaccine candidates containing a 3′ genomic promoter mutation and L polymerase mutations are attenuated and protective in non-human primates

Previously, we identified several attenuating mutations in the L polymerase protein of human parainfluenza virus type 2 (HPIV2) and genetically stabilized those mutations using reverse genetics (Nolan et al., 2005). Here we describe the discovery of an attenuating mutation at nucleotide 15 (15(T→C))...

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Hauptverfasser: Nolan, Sheila M., Skiadopoulos, Mario H., Bradley, Konrad, Kim, Olivia S., Bier, Stacia, Amaro-Carambot, Emerito, Surman, Sonja R., Davis, Stephanie, St. Claire, Marisa, Elkins, Randy, Collins, Peter L., Murphy, Brian R., Schaap-Nutt, Anne
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040028/
https://ncbi.nlm.nih.gov/pubmed/17658669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2007.06.028
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