PEG-b-PPA/DNA micelles improve transgene expression in rat liver through intrabiliary infusion

We have developed a new block copolymer gene carrier that comprises of a polyethylene glycol segment and a degradable cationic polyphosphoramidate (PPA) segment. This PEG-b-PPA copolymer carrier formed micelles upon condensation with plasmid DNA in aqueous solution. PEG-b-PPA/DNA micelles exhibited...

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Hlavní autoři: Jiang, Xuan, Dai, Hui, Ke, Chyan-Ying, Mo, Xiao, Torbenson, Michael S., Li, Zhiping, Mao, Hai-Quan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2035949/
https://ncbi.nlm.nih.gov/pubmed/17640758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2007.06.014
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