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Transient Depletion of Kupffer Cells Leads to Enhanced Transgene Expression in Rat Liver Following Retrograde Intrabiliary Infusion of Plasmid DNA and DNA Nanoparticles

In this report, we have demonstrated that by temporarily removing Kupffer cells (KCs), the transgene expression levels mediated by retrograde intrabiliary infusion (RII) of plasmid DNA, polyethylenimine-DNA, and chitosan nanoparticles were enhanced by 1,927-, 131-, and 23,450-fold, respectively, in...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Dai, Hui, Jiang, Xuan, Leong, Kam W., Mao, Hai-Quan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135268/
https://ncbi.nlm.nih.gov/pubmed/21091274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2010.146
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