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Functional Characterization of Pathogenic Human MSH2 Missense Mutations in Saccharomyces cerevisiae

Hereditary nonpolyposis colorectal cancer (HNPCC) is associated with defects in DNA mismatch repair. Mutations in either hMSH2 or hMLH1 underlie the majority of HNPCC cases. Approximately 25% of annotated hMSH2 disease alleles are missense mutations, resulting in a single change out of 934 amino aci...

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書誌詳細
主要な著者: Gammie, Alison E., Erdeniz, Naz, Beaver, Julia, Devlin, Barbara, Nanji, Afshan, Rose, Mark D.
フォーマット: Artigo
言語:Inglês
出版事項: Copyright © 2007 by the Genetics Society of America 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2034637/
https://ncbi.nlm.nih.gov/pubmed/17720936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.107.071084
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