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Functional Characterization of Pathogenic Human MSH2 Missense Mutations in Saccharomyces cerevisiae
Hereditary nonpolyposis colorectal cancer (HNPCC) is associated with defects in DNA mismatch repair. Mutations in either hMSH2 or hMLH1 underlie the majority of HNPCC cases. Approximately 25% of annotated hMSH2 disease alleles are missense mutations, resulting in a single change out of 934 amino aci...
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| Hoofdauteurs: | , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Copyright © 2007 by the Genetics Society of America
2007
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2034637/ https://ncbi.nlm.nih.gov/pubmed/17720936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.107.071084 |
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