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Biochemical basis for dominant mutations in the Saccharomyces cerevisiae MSH6 gene

Here, the ATP-binding, ATP hydrolysis, mispair-binding, sliding clamp formation, and Mlh1–Pms1 complex interaction properties of dominant mutant Msh2–Msh6 complexes have been characterized. The results demonstrate two mechanisms for dominance. In one, seen with the Msh6-S1036P and Msh6-G1067D mutant...

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Detalhes bibliográficos
Main Authors: Hess, Martin T., Mendillo, Marc L., Mazur, Dan J., Kolodner, Richard D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1334674/
https://ncbi.nlm.nih.gov/pubmed/16407100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510078103
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