Chimeric Saccharomyces cerevisiae Msh6 protein with an Msh3 mispair-binding domain combines properties of both proteins

Msh2–Msh3 and Msh2–Msh6 are two partially redundant mispair-recognition complexes that initiate mismatch repair in eukaryotes. Crystal structures of the prokaryotic homolog MutS suggest the mechanism by which Msh6 interacts with mispairs because key mispair-contacting residues are conserved in these...

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Bibliographic Details
Main Authors: Shell, Scarlet S., Putnam, Christopher D., Kolodner, Richard D.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1904149/
https://ncbi.nlm.nih.gov/pubmed/17573527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0704148104
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