Multiplexing mutation rate assessment: determining pathogenicity of Msh2 variants in Saccharomyces cerevisiae

Despite the fundamental importance of mutation rate as a driving force in evolution and disease risk, common methods to assay mutation rate are time-consuming and tedious. Established methods such as fluctuation tests and mutation accumulation experiments are low-throughput and often require signifi...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Genetics
Main Authors: Ollodart, Anja R, Yeh, Chiann-Ling C, Miller, Aaron W, Shirts, Brian H, Gordon, Adam S, Dunham, Maitreya J
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2021
Teme:
Developmental and Behavioral Genetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8225350/
https://ncbi.nlm.nih.gov/pubmed/33848333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/genetics/iyab058
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