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Sugar binding induces an outward facing conformation of LacY

According to x-ray structure, the lactose permease (LacY) is a monomer organized into N- and C-terminal six-helix bundles that form a deep internal cavity open on the cytoplasmic side with a single sugar-binding site at the apex. The periplasmic side of the molecule is closed. During sugar/H(+) symp...

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Hlavní autoři: Smirnova, Irina, Kasho, Vladimir, Choe, Jun-Yong, Altenbach, Christian, Hubbell, Wayne L., Kaback, H. Ronald
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2034228/
https://ncbi.nlm.nih.gov/pubmed/17925435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708258104
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