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Overlapping roles for the histone acetyltransferase activities of SAGA and Elongator in vivo

Elp3 and Gcn5 are histone acetyltransferases (HATs) that function in transcription as subunits of Elongator and SAGA/ADA, respectively. Here we show that mutations that impair the in vitro HAT activity of Elp3 confer typical elp phenotypes such as temperature sensitivity. Combining an elp3Δ mutation...

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Detalhes bibliográficos
Main Authors: Wittschieben, Birgitte Ø., Fellows, Jane, Du, Wendy, Stillman, David J., Svejstrup, Jesper Q.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC203375/
https://ncbi.nlm.nih.gov/pubmed/10856249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.12.3060
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