ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice

The discovery of the ABCA1 lipid transporter has generated interest in modulating human plasma HDL levels and atherogenic risk by enhancing ABCA1 gene expression. To determine if increased ABCA1 expression modulates HDL metabolism in vivo, we generated transgenic mice that overexpress human ABCA1 (h...

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Main Authors: Vaisman, Boris L., Lambert, Gilles, Amar, Marcelo, Joyce, Charles, Ito, Toshimitsu, Shamburek, Robert D., Cain, William J., Fruchart-Najib, Jamila, Neufeld, Edward D., Remaley, Alan T., Brewer, H. Bryan, Santamarina-Fojo, Silvia
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2001
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC203026/
https://ncbi.nlm.nih.gov/pubmed/11457883
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