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Characterization of placental cholesterol transport: ABCA1 is a potential target for in utero therapy of Smith–Lemli–Opitz syndrome

Patients with Smith–Lemli–Opitz syndrome (SLOS) are born with multiple congenital abnormalities. Postnatal cholesterol supplementation is provided; however, it cannot correct developmental malformations due to in utero cholesterol deficit. Increased transport of cholesterol from maternal to fetal ci...

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Autors principals: Lindegaard, Marie L., Wassif, Christopher A., Vaisman, Boris, Amar, Marcelo, Wasmuth, Elizabeth V., Shamburek, Robert, Nielsen, Lars B., Remaley, Alan T., Porter, Forbes D.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581429/
https://ncbi.nlm.nih.gov/pubmed/18775956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn278
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