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Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization

Mitochondrial outer-membrane permeabilization by pro-apoptotic Bcl-2 family members plays a crucial role in apoptosis induction. However, whether this directly causes the release of the different mitochondrial apoptogenic factors simultaneously is currently unknown. Here we report that in cells or w...

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Hlavní autoři: Arnoult, Damien, Gaume, Brigitte, Karbowski, Mariusz, Sharpe, Juanita C., Cecconi, Francesco, Youle, Richard J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2003
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC202365/
https://ncbi.nlm.nih.gov/pubmed/12941691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg423
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