Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes

Alkylation of DNA at the O(6)-position of guanine is one of the most critical events leading to mutation, cancer, and cell death. The enzyme O(6)-methylguanine-DNA methyltransferase repairs O(6)-methylguanine as well as a minor methylated base, O(4)-methylthymine, in DNA. Mouse lines deficient in th...

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Main Authors: Kawate, Hisaya, Sakumi, Kunihiko, Tsuzuki, Teruhisa, Nakatsuru, Yoko, Ishikawa, Takatoshi, Takahashi, Seiichi, Takano, Hiroshi, Noda, Tetsuo, Sekiguchi, Mutsuo
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1998
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC20223/
https://ncbi.nlm.nih.gov/pubmed/9560238
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