Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes

Alkylation of DNA at the O(6)-position of guanine is one of the most critical events leading to mutation, cancer, and cell death. The enzyme O(6)-methylguanine-DNA methyltransferase repairs O(6)-methylguanine as well as a minor methylated base, O(4)-methylthymine, in DNA. Mouse lines deficient in th...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Kawate, Hisaya, Sakumi, Kunihiko, Tsuzuki, Teruhisa, Nakatsuru, Yoko, Ishikawa, Takatoshi, Takahashi, Seiichi, Takano, Hiroshi, Noda, Tetsuo, Sekiguchi, Mutsuo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20223/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9560238/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.9.5116
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