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Pyrimethamine-resistant dihydrofolate reductase enzymes of P. falciparum are not enzymatically compromised in vitro

Plasmodium falciparum, the protozoan that causes the most lethal form of human malaria, has been controlled principally by two safe, affordable drugs, chloroquine and sulfadoxine-pyrimethamine (SP). Studies in the laboratory and in the field have demonstrated that resistance to SP depends on non-syn...

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Bibliografische gegevens
Hoofdauteurs: Sandefur, Conner I., Wooden, Jason M., Quaye, Isaac K., Sirawaraporn, Worachart, Sibley, Carol Hopkins
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2007
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2020854/
https://ncbi.nlm.nih.gov/pubmed/17451822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molbiopara.2007.03.009
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