A novel p38α MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model

BACKGROUND: An accumulating body of evidence is consistent with the hypothesis that excessive or prolonged increases in proinflammatory cytokine production by activated glia is a contributor to the progression of pathophysiology that is causally linked to synaptic dysfunction and hippocampal behavio...

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Detalhes bibliográficos
Main Authors: Munoz, Lenka, Ranaivo, Hantamalala Ralay, Roy, Saktimayee M, Hu, Wenhui, Craft, Jeffrey M, McNamara, Laurie K, Chico, Laura Wing, Van Eldik, Linda J, Watterson, D Martin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014744/
https://ncbi.nlm.nih.gov/pubmed/17784957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-4-21
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