Glia as a Therapeutic Target: Selective Suppression of Human Amyloid-β-Induced Upregulation of Brain Proinflammatory Cytokine Production Attenuates Neurodegeneration

A corollary of the neuroinflammation hypothesis is that selective suppression of neurotoxic products produced by excessive glial activation will result in neuroprotection. We report here that daily oral administration to mice of the brain-penetrant compound 4,6-diphenyl-3-(4-(pyrimidin-2-yl)piperazi...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Ranaivo, Hantamalala Ralay, Craft, Jeffrey M., Hu, Wenhui, Guo, Ling, Wing, Laura K., Van Eldik, Linda J., Watterson, D. Martin
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2006
Assuntos:
Neurobiology of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674428/
https://ncbi.nlm.nih.gov/pubmed/16407564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4652-05.2006
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